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Don't know for sure but I have a few ideas. As someone who grew up in the 60s and did alot of psychotimetics such as LSD, Mescaline and Psilocybin I can remember times when I was worn out and apathetic after tripping. And it lasted too damn long. MDA (the love drug at the time) seemed much easier to recover from. At the time I went to see a shrink friend and he gave me an anti-depressive of the tricyclic variety and it worked great. Of course I didn't like the side effects, so I stopped using both. These drugs work mostly with norepinephrine and slightly with serotonin. I think most drugs, when used beyond recreation and exploration can cause serious depression. There is always a payback that takes more time than we like to recuperate.
Prozac should help if given free reign. (No drugs too) If anything one will feel better no matter what is happening. Prozac seems to improve even the healthy individual. I have heard of show dogs using it. And they are the alphas.
We had MDA, no MDMA, but they are quite similar in many respects.
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josh
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